Charming country bumpkin Duane Bradley takes a motel room in New York with a basket and a backpack. In a flash back-series we learn the basket contains his surgically removed Siamese twin who is not only physically deformed so badly the doctors hesitated to consider him a human, but is also the vindictive drive of their trip, with the purpose to kill off all those he blames. But in the reception of one of those doctors, Duane gets his first ever date, with the receptionist, and wants to start a positive life too - when the freak twin escapes, the scene is set for a grim finale.