Marmaduke, the world's most lovable Great Dane, leaps from comic strip fame (appearing in 600 newspapers in over 20 countries) to big screen stardom in this family comedy event. A suburban family moves to a new neighborhood in Orange County, California with their large yet lovable Great Dane, who has a tendency to wreak havoc in his own oblivious way. But it's not all living large for the Duke, who finds that fitting in with his new four-legged friends - and a potential romantic interest - isn't always easy for a super-sized teenage dog. Owen Wilson gives the beloved Great Dane his voice in the film, which also features the voices of Fergie, George Lopez, Emma Stone and Kiefer Sutherland.