The Ambassador of Cuba was killed in New York. To prevent another attack of the terrorists at the US-Cuba-summit in Prague the CIA sends one of their best federal agents, Michael Dane (Dolph Lundgren). The suspected killer Nikita is a lesbian club owner, Simone Rosset. But as usual everything is much more complicated than it seemed at first; and therefore Dane has to work much more with his brain than with his muscles to survive.