The Mousekewitz family has settled in America: Pa now runs a small violin shop in a little town in the Far West, a wild and dangerous country. Fievel lives there and remains as boisterous a mouse-boy, playful and with a knack for getting into all kinds of trouble and adventure, often opposing Cat R.Waul's gang, who has also moved West and hooks up with Chula the Tarantula. Fortunately so did Fievel's simpleton feline friend, Tiger, and there is a tough sheriff who can handle the bad cat thugs.