UFC Fight Night: Marquardt vs. Palhares, also known as UFC Fight Night 22 (and formerly known as UFC Fight Night: Maia vs. Belcher) was a mixed martial arts event held by the Ultimate Fighting Championship on September 15, 2010 at the Frank Erwin Center in Austin, Texas. The event also served as a lead in to the season premiere of The Ultimate Fighter: Team GSP vs. Team Koscheck.