When the young mouse, Max's family is killed by exterminators, he is forced to move to his Aunt's home under the White House in Washington D.C.. There he finds life more lively than he ever thought possible with his friends, the crusading Berkeley, the roguish Jammit, the frazzled and periodically exploding Muggle the Lab Rat, and Moze, the hip cockroach as they go about their lives in the US President's residence.