Gale Sayers joins the Chicago Bears and is befriended by Brian Piccolo, an over-achieving running back. Although they compete for the same spot on the team, and despite the fact that Sayers is black and Piccolo white, they become roommates on the road and very close friends, especially when Sayers is injured and Piccolo helps his recovery. Later, they and their wives must both deal with the harsh reality of Piccolo's cancer.