Madie Levrington is a neurotic, wealthy woman who escapes from a New York mental institution where her unwholesome husband had her committed to avoid the trial of an expensive divorce. She manages by taking her doctor hostage and leaving him behind in an open field, and flees into the night. Madie hitches a ride back to California with Charles Callahan, a moody, debt-ridden truck driver. Madie and Charles eventually fall in love while evading an assortment of villains including a pair of thugs hired by Madie's husband to prevent her from returning to California, and a repo man sent to reclaim Charles' truck.