- Fast. Furious. Fun.
- When the series debuted in 2003, it was hounded by critics who said it wouldn't last very long. For the 2004-2005 season, it was the only show NBC renewed for a second season.
- The name on a fake passport Ed Deline uses (Alan Bodillion Treherne) when going into hiding, after being accused of Mary's father's murder, is the name of the "sidekick" character James Caan played in El Dorado (1967), with John Wayne.
- The shot of Danny driving his Camaro down the Vegas strip was used in the opening credits during every season of the show. It was attached to Josh Duhamel's billing. The shot of Molly Sims rising from the pool in a bikini was used on her billing in the first four seasons, and only removed in the final year.
- Josh Duhamel, James Lesure, Vanessa Marcil, and Molly Sims are the only cast members to appear in all one hundred six episodes.
- The casino, out of which Hiro Nakamura and Ando Masahashi are thrown out, in season one, episode four of Heroes (2006), is the Montecito.
- In the opening scene for the pilot of Knight Rider (2008), Micheal is playing poker at the Monticito.
- Josh Duhamel holds the record among the cast for most appearances as his character. In addition to appearing in all one hundred six episodes, he also played Danny McCoy in three episodes of Crossing Jordan (2001). Vanessa Marcil appeared in two of those, while Molly Sims and James Caan each guest-starred once.
- Different theme songs have been used, depending on where, how, or when the show is viewed. In Australia, Portugal, UK, the Netherlands, and other countries, the theme song is Let It Ride by Charlie Clouser, while in other countries, such as the U.S. and Canada, the theme song is A Little Less Conversation (the Junkie XL mix) by Elvis Presley. For the American DVD, as well as the episodes available for viewing on NBC's website, the Clouser song is used. Occasionally, there have been different opening songs for some episodes. For example, Las Vegas: Pharaoh 'Nuff (2007) opened with "Crazy Bitch" by Buckcherry.
- Two of the cast members married people who guest-starred on the show. Josh Duhamel married Fergie, after she appeared in a guest spot with The Black Eyed Peas in Las Vegas: Montecito Lancers (2004). Nikki Cox married Jay Mohr, after he guest-starred in Las Vegas: Whale of a Time (2005).
- There are 5,230 surveillance cameras in the Montecito.
- Based on an idea by Don Johnson, who suggested the title "Casino Eye".
- Four of the cast members appeared on 1 vs. 100 (2006), season one, episode six: Josh Duhamel, James Lesure, Nikki Cox, and Molly Sims. All of them were eliminated without winning any money for charity.
- In one of the third season episodes, Martin (Barry Bostwick) asks Ed Deline about the character Sonny Corleone from The Godfather (1972), to which Ed replies "Never seen it". In a season two episode, Ed is shown talking to Mike Cannon (James Lesure) about a scene in The Godfather (1972) dealing with the Sonny Corleone character. James Caan (Ed Deline) also played Sonny Corleone.
- The location of the fictional Montecito has changed from season to season. Some of the first episodes were taped at the Monte Carlo Resort and Casino, which is located at the intersection of Tropicana and the Vegas Strip (next to New York, New York, and across from the MGM Grand). (They closed down the strip on at least one occasion at that block to film a car scene.) Because of its similarity to Mandalay Bay, many of the show's visuals place the Montecito at the southern end of The Strip, albeit usually across the street from Mandalay Bay on the airport side of Las Vegas Boulevard. The exact location and rotation of the building, seems to vary a lot within this area, indeed, the CGI zoom shots of the building exterior in the season two episode, "Montecito Lancers", shows the building in three slightly differing locations for three different shots. Many of Mandalay Bay's interiors and exteriors (including its wave pool) have been used as Montecito exteriors, although the actual set of Montecito is located at Culver Studios, in Culver City, California, so the interiors are a replica of the Mandalay Bay. These studios are where Gone with the Wind (1939) was filmed. During the first season of the show, many of the Montecito's suites overlooked various parts of the middle part of the Strip, placing the hotel near where the Venetian, the Flamingo, or the Mirage are currently, before the more consistent location at the southern end of the Strip was finalized. In season three, Ed Deline's office appears to be in the middle of the strip, overlooking Harrah's, Caesar's Palace, the Mirage, and the Venetian, which puts the Montecito near where Treasure Island is located. This is inconsistent with the flyover shots of the Montecito, which would place Ed's office over two miles away. Closer examination of the window scene, shows that the Mirage's marquee over their driveway has been edited to read "Montecito". In season four, episode two (at around thirty-four minutes) there is a scene in Ed Deline's office, where again we can see an overview of The Mirage and Caesar's Palace. Again, it's a confirmation that Ed Deline's office would be where Treasure Island is located. According to an episode that originally aired in December 2005, the Montecito is located about 1.5 miles from the Wynn Las Vegas. It's possible that this distance is in a straight line, as opposed to actual driving distance. This distance is inconsistent with long shots, that place the Montecito near the airport and Mandalay Bay, but is in line with season three's visual references noted above. Other episodes show aerial shots of the Montecito, that make it appear to be situated at the corner of Giles Street and Reno Avenue, about half a mile from the Mandalay Bay.
- Show was cancelled due to the writers' strike in 2008. Show ended with a cliffhanger.
- Don Johnson was considered for Ed Deline.
- In Heroes: Chapter Four 'Collision' (2006) and Heroes: Chapter Five 'Hiros' (2006), Hiro, Ando, Nathan, and Niki all stay at the Montecito. In Heroes: Chapter Fourteen 'Distractions' (2007), Ando and Hiro wear badges that match the logos seen on this show.
- Character error: In the title sequence, pit boss Nessa Holt (Marsha Thomason) dramatically deals out a Jack of Hearts at a full Blackjack table. However, the chip box is locked on that table, therefore the table is closed and no one would be able to play. Surely the "Ice Queen" and Vegas' greatest pit boss should know that.